GasGasGas - Primary FRCA ’fun’

GasGasGas - Michaelis Menten Enzymes!

The whirlwind that is enzyme kinetics in the human body for the FRCA primary exam, Enjoy!
Show Notes @: https://gasgasgas.uk/gasgasgas-michaelis-menten-mass-action-enzyme-kineticsgasgasgas/
MICHAELIS MENTEN – MASS ACTION – ENZYME KINETICS - FIRST ORDER - ZERO ORDER - ALLOSTERIC - VMAX - KM

GasGasGas - Atracurium

Frca Primary Podcast looking at the properties of Atracurium, further introduction to the action of neuromuscular blocking agents and that all important exam structure!
Shownotes @ : https://gasgasgas.uk/gasgasgas-atracurium-frca/
ATRACURIUM, LAUDANOSINE, HOFFMAN ELIMINATION, FRCA, FRCA PRIMARY, CIS-ATRACURIUM, BENZYLISOQUINOLINIUM

GasGasGas - Thiopentone

Talking Thiopentone, the bits needed for the exam and the practical bits of when it might get used (rarely, unless the boss happens to be from the 1940's) or you're doing obstetrics.
Shownotes @: https://gasgasgas.uk/gasgasgas-thiopentone/
THIOPENTONE, BARBITUATES, TAUTOMERISM, TAUTOMER, PKA, HALFLIFE, PORPHYRIA

GasGasGas - Compartmentalised Volatiles and a brief jaunt with Sevoflurane

This episode explores how volatile anaesthetics behave and affect patients.
Shownotes @: https://gasgasgas.uk/gasgasgas-compartmentalised-volatiles-and-a-brief-jaunt-with-sevoflurane/
Chiefly thinking about how the compartments in a breathing circuit and patient interplay to achieve depth / maintain anaesthetic depth and emerge from anesthesia.
Absolutely worth a listen to get your head around compartments and also starting thinking about blood gas and oil gas partition coefficients
VOLATILE AGENTS, SEVOFLURANE, ANAESTHETIC GASES, SATURATED VAPOUR PRESSURE, BOILING POINT, BLOOD GAS PARTITION CO-EFFICIENT.

GasGasGas - Hepatic Clearance

This primary FRCA podcast episode introduces clearance and then descends into bedlam trying to think about how the liver really clears drugs on a kinetics level.
Shownotes @: https://gasgasgas.uk/gasgasgas-hepatic-clearance/
I am not making you run for the hills by talking phase 1 and 2 metabolism ,CYP and all that jazz, that's for later.
Clearance, First order, Zero order, Kinetics, FRCA, Primary, Anaesthetics, Fun

GasGasGas - pKa

We're talking pKa and all the delightful brain strain associated (or disassociated!) from it
pKa is a concept which is critical to how drugs cross membranes to their respective active sites.
Shownotes @: https://gasgasgas.uk/gasgasgas-pka/
pKa, Association and disassociation coefficient, pharmacokinetics, 

GasGasGas - Volume of Distribution

This Primary FRCA Podcast episode talks up Volume of distribution,
A pharmacological concept used as an introduction to compartmentalising humans into a variety of volumes in order to think about how drugs (or chemicals, or really anything even water....) distributes around a human.
Show Notes @: https://gasgasgas.uk/gasgasgas-volume-of-distribution/
VOD volume of distribution, pharmacokinetics, FRCA, Primary, Anaesthetics

GasGasGas - Fentanyl

FRCA Primary Podcast
Were talking the core fentanyl waffle, a jump into the opiate GPCRs Receptors
And closing up with some talk on using fentanyl in day to day practice and a brief introduction to pKa
Show Notes @: https://gasgasgas.uk/fentanyl-frca-primary-exam/
FRCA Primary Anaesthetics, Fentanyl, PKA, VOD, CYP2EI, norfentanyl

GasGasGas - Propofol

FRCA Primary Podcast - 
 
Were talking the core propofol waffle, what PKa is and how to think of it, and a bit about how to apply propofol to day to day work.
Show Notes @: https://gasgasgas.uk/gasgasgas-propofol/
Propofol FRCA Primary Anaesthetics PKa 2,6 di-isopropylphenol

GasGasGas - Rocuronium

FRCA Primary podcast covering the pharmacodynamics and pharmacokinetics of rocuronium
An introduction and full breakdown of rocuronium.
https://gasgasgas.uk/gasgasgas-rocuronium/