GasGasGas - Anaesthetic Science for Anaesthesia!

Neuraxial Opioid Kinetics: Spinal & Epidural Analgesia for Regional Anaesthesia

In this explainer episode of GasGasGas, we make our descent into the joyful complexities of neuraxial opiate pharmacology.
Why do we bother putting opiates into this space at all? What governs their journey, how do they behave once administered, and what clinical pearls can be drawn from their behaviour? This episode follows the journey of a single opioid molecule through the fatty labyrinth of the epidural space, across barriers, and into its final destination: the dorsal horn of the spinal cord, before it potters away to realms of mischief in the brainstem.
Show notes at: https://gasgasgas.uk/neuraxial-opiate-kinetics-for-the-frca-primary/
================================================
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
================================================
Dr Gas Lurks On: 
> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
> FaceBook: Facebook - Gas Gas Gas
> Website: www.gasgasgas.uk
================================================
Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
================================================
Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 
Sassy Jazzy - La Faena - Free music archive
================================================
"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."
© GasGasGas-Podcast 2025

Diamorphine (Golden Brown): Opioid Pharmacology for Anaesthetic Practice

In this episode of Gas, Gas, Gas, we drill a figurative oil well into the pharmacology of diamorphine — also known by its more notorious street name, Heroin/Smack/Golden Brown. Diamorphine is a synthetic diacetylated derivative of morphine, and this episode details its mechanism of action, clinical applications, pharmacokinetics, pharmacodynamics, and side effect profile. The episode is structured to support FRCA Primary revision with an irrelevant clinical anecdote (but sound advice I would argue) and exam-focus.
Show notes at: https://gasgasgas.uk/diamorphine-for-the-frca-primary/ 
================================================
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
================================================
Dr Gas Lurks On: 
> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
> FaceBook: Facebook - Gas Gas Gas
> Website: www.gasgasgas.uk
================================================
Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
================================================
Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 
Sassy Jazzy - La Faena - Free music archive
================================================
"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."
© GasGasGas-Podcast 2025

Oxycodone: Synthetic Opioid Analgesic for Perioperative Pain

We are plunging into the pharmacology of oxycodone, a potent semi-synthetic opioid analgesic widely used in perioperative and chronic pain settings. We explore oxycodone's mechanism of action, pharmacokinetics, and pharmacodynamics
We dissect its action on mu-opioid receptors, compare it to morphine and other opioids, and review evidence regarding oral vs intravenous formulations, metabolism via CYP450 enzymes + implications for renal and hepatic impairment.
It's lost is license for prolonged release versions in acute pain!
Show notes at: https://gasgasgas.uk/oxycodone-for-the-frca-primary/
================================================
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
================================================
Dr Gas Lurks On: 
> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
> FaceBook: Facebook - Gas Gas Gas
> Website: www.gasgasgas.uk
================================================
Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
================================================
Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 
Sassy Jazzy - La Faena - Free music archive
================================================
"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."
© GasGasGas-Podcast 2025

Methadone: Long-Acting Opioid for Chronic Pain in Anaesthesia

In this episode of the GasGasGas Primary FRCA podcast, we explore methadone, its pharmacology (pharmacodynamics and pharmacokinetics), diverse receptor activity, and its clinical uses.
While traditionally associated with managing opioid dependency, methadone’s unique pharmacodynamics and potential utility may have been overlooked given its other uses…
Show notes at: https://gasgasgas.uk/methadone-for-the-frca-primary/
================================================
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
================================================
Dr Gas Lurks On: 
> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
> FaceBook: Facebook - Gas Gas Gas
> Website: www.gasgasgas.uk
================================================
Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
================================================
Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 
Sassy Jazzy - La Faena - Free music archive
================================================
"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."
© GasGasGas-Podcast 2025

Tramadol: Atypical Opioid Analgesic Pharmacology & Clinical Use

This episode takes a dive into the detailed pharmacology of Tramadol focussing on the content  for the FRCA Primary exam. We explore its unique multi-mechanism analgesic action, pharmacokinetics, clinical uses, and key points.
Show notes at: https://gasgasgas.uk/tramadol-for-frca-primary-exam/
================================================
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
================================================
Dr Gas Lurks On: 
> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
> FaceBook: Facebook - Gas Gas Gas
> Website: www.gasgasgas.uk
================================================
Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
================================================
Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 
Sassy Jazzy - La Faena - Free music archive
================================================
"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."
© GasGasGas-Podcast 2025

Alfentanil: Short-Acting Synthetic Opioid Pharmacology for the FRCA and your Anaesthetic Practice

In this episode of GasGasGas, we explore Alfentanil, a short-acting μ-opioid receptor agonist pivotal for anaesthetic practice. Discovered in 1976 by Janssen Pharmaceuticals, Alfentanil remains a super handy agent, especially for (modified) rapid-sequence inductions and acute pain management.
Show notes at https://gasgasgas.uk/alfentanil-for-the-frca-primary/ 
================================================
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
================================================
Dr Gas Lurks On: 
> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
> FaceBook: Facebook - Gas Gas Gas
> Website: www.gasgasgas.uk
================================================
Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
================================================
Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 
Sassy Jazzy - La Faena - Free music archive
================================================
"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."
© GasGasGas-Podcast 2025

Target-Controlled Infusion (TCI): Pharmacokinetic Models for TIVA Anaesthesia

TIVA Models for Propofol particularly the: Marsh, Schnider, and Eleveld TCI models.
Avoid the classic pitfalls of blindly trusting a pump. If you’re prepping for the FRCA or just want to master the ‘why’ behind TCI behaviour, you’re in the right place. Sorry to the USA folks stuck with mcg/kg/min!
Show notes at: https://gasgasgas.uk/tiva-models-for-propofol/
================================================
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
================================================
Dr Gas Lurks On: 
> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
> FaceBook: Facebook - Gas Gas Gas
> Website: www.gasgasgas.uk
================================================
Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
================================================
Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 
Sassy Jazzy - La Faena - Free music archive
================================================
"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."
© GasGasGas-Podcast 2025

Vivacast 16 - Misplacing 1000ml of circulating volume on the floor, Nerve conduction physiology, pH and acid base derangement

In this VivaCast episode, we simulate a comprehensive FRCA Primary physiology viva covering three key topics: physiological response to acute blood loss, nerve conduction and classification, and acid-base balance including pH regulation and anion gap interpretation.
Show Notes @ https://gasgasgas.uk/hemorrhage-nerves-ph/
================================================
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
================================================
Dr Gas Lurks On: 
> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
> FaceBook: Facebook - Gas Gas Gas
> Website: www.gasgasgas.uk
================================================
Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
================================================
Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 
Sassy Jazzy - La Faena - Free music archive
================================================
"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."
© GasGasGas-Podcast 2025

Interview - The first three months of UK anaesthetics, insights and learning - Dr James Smith

Welcome to a special interview edition of GasGasGas – the podcast that explores anaesthetic life in all its glorious detail, venturing out into its terrifying, and human dimensions.
I want those thinking about anaesthetics to gain insight, and I want everyone else Post IAC to remember the IAC experience and focus on what we can do to make the IAC time maximally useful for our colleagues.Today, host James sits down with James, a CT2 ACCS anaesthetic trainee to explore the real story behind those first few months in anaesthetic training.
================================================
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
================================================
Dr Gas Lurks On: 
> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
> FaceBook: Facebook - Gas Gas Gas
> Website: www.gasgasgas.uk
================================================
Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
================================================
Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 
Sassy Jazzy - La Faena - Free music archive
================================================
"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."
© GasGasGas-Podcast 2025
 
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
Dr Gas Lurks On: 
BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
FaceBook: Facebook - Gas Gas Gas
Website: www.gasgasgas.uk
Disclaimer / Sage Advice
All content is educational in nature and never intended to be acted upon.
This information is not a suitable substitute for medical advice.
Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
Music Credit:
Streets of Sant Ivo - Mid-Air Machine - Free music archive // Sassy Jazzy - La Faena - Free music archive

VivaCast 15 - Clinical Case PsuedoAneurysm

In this VivaCast episode, we present a complex clinical scenario involving an intravenous drug user (IVDU) presenting with an infected pseudoaneurysm.
Tom grapples with the challenges of these high BBV risk cases and managed local anaesthetic toxicity as it all goes terribly pear shaped!
Show Notes Here!
================================================
GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
================================================
Dr Gas Lurks On: 
> BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social)
> X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X
> FaceBook: Facebook - Gas Gas Gas
> Website: www.gasgasgas.uk
================================================
Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. 
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
================================================
Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive 
Sassy Jazzy - La Faena - Free music archive
================================================
"This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder."
© GasGasGas-Podcast 2025